Developmental variation in Phase I enzymes has what impact on pediatric prescribing?

Developmental variation in Phase I enzymes has what impact on pediatric prescribing?

A. Children and adolescents should always be prescribed higher than adult doses per weight due to high enzyme activity.
B.
Prescribing dosages will vary based the childs age and developmental activity of enzyme, at times requiring lower than adult doses and other times higher than adult doses based on the age of the child/adolescent.

C. None, phase I enzymes are stable through out childhood and adolescents
D. Children should usually be prescribed lower than adult doses per weight due to low enzyme activity until puberty