CHOLINERGIC ANTAGONISTS / ANTICHOLINERGIC DRUGS
| CHOLINERGIC ANTAGONISTS / ANTICHOLINERGIC DRUGS | ||||
| DRUG CLASS | DRUGS | MECHANISM OF ACTION | INDICATIONS | SPECIAL FEATURES |
|
MOTION SICKNESS DRUGS |
Scopolamine |
Unknown mechanism in the CNS
|
Prevention of motion sickness and postoperative nausea and vomiting.
|
Scopolamine has the highest propensity to cause CNS symptoms compared to all the other anticholinergics |
|
GASTROINTESTINAL DISORDER DRUGS |
Dicyclomine |
Competitive antagonism at M2 receptors.
|
Irritable bowel syndrome Minor diarrhea |
|
|
OPHTHALMOLOGY DRUGS |
Atropine |
Competitive antagonism at all M receptors.
|
Retinal examination Prevention of synechiae after surgery
|
|
|
RESPIRATORY (ASTHMA) DRUGS |
Ipratropium |
Competitive non-selective antagonism at M receptors.
|
Prevention and relief of acute episodes of bronchospasms |
|
|
URINARY DRUGS |
Oxybutynin |
Slightly M2 selective muscarinic antagonist.
|
Urge incontinence Postoperative spasms |
|
|
DRUGS FOR CHOLINERGIC POISONING |
Atropine |
Non-selective competitive antagonist at all muscarinic receptors in the CNS and periphery.
|
Mandatory antidote for severe cholinesterase inhibitor poisoning |
|
|
Pralidoxime |
Very high affinity for phosphorus atom but does not enter CNS.
|
Usual antidote for early stage (48 hours) cholinesterase inhibitor poisoning. |
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kindly answer the missing parts and put some other drugs
Complete Answer:
