Mr. Henderson is a 69-year-old man case

Mr. Henderson is a 69-year-old man who presents for evaluation and care for depression. His wife died 6 months

ago following a difficult 2 years with breast cancer. His primary complaint is that he just does not look forward to

anything anymore. He cannot get interested in his children and grandchildren, he no longer enjoys any of his

hobbies because he and his wife used to do them together. He does not sleep well, and wakes up frequently during

the night. He also admits to thinking more and more about dying himself, although he expressly denies suicidal

ideation. His medical history is significant for coronary artery disease, osteoarthritis, hypothyroidism, hypertension,

and dyslipidemia. He also has atrial fibrillation and is on warfarin for emboli prophylaxis, but he does not remember

the names of all of his other medications. When considering pharmacotherapy for Mr. Henderson, the PMHNP

considers that which of the following SSRIs is safest with respect for potential drug interactions?

A. Fluoxetine

B. Paroxetine

C. Escitalopram

D. Sertraline