P. R. is a 24-year-old male who presents to urgent care with complaints of rectal bleeding and weakness. Five day

P. R. is a 24-year-old male who presents to urgent care with complaints of rectal bleeding and weakness. Five days ago he noticed bright red blood in his stools.  His daily bowel movements have increased to five or six with significant diarrhea.  He states that urges to move his bowels have rapid onset but there is not incontinence.  He has not traveled outside of the city, been hospitalized or received antibiotics recently.

He has a strong positive family history of autoimmune disease on the maternal side.  His mother has SLE.  He maternal grandmother had Graves disease and his aunt  has myasthenia gravis.

A protosigmoidoscopy revealed significant pseudopolyps and inflammation and ulceration were seen in the rectum and the sigmoid colon.

1. What are the top 2-3 diagnoses to think about in this case?