Typically more frequent measurements are taken at the start of the pharmacokinetic process, where the rates are faster, than the slower later stages of the process. Consider an intravenous bolus of 500 mg administered to a patient, and the plasma drug concentration measurements reported in the table below. Estimate the elimination rate constant via least squares regression. Please enter your response as X.XX h-1.
Time (h) | 1 | 2 | 3 | 4 | 6 | 8 | 10 |
Concentration (mg/L) | 75 | 53 | 34 | 23 | 13 | 9 | 5 |