LACTOSE MONOHYDRATE

LACTOSE MONOHYDRATE:

Bulk density = 33 from Carr’s index

Amount in each capsule: 211.39 mg

CALCIUM CARBOHYDRATE:

Bulk density = 19.2

Amount in each capsule: 544.4 mg

1.  Your calculation of the required amount of lactose used the manual filling of capsule by the drug and the diluent separately. Comment on how your calculations are compared with the APF25 Table for the recommended hard capsule sizes and the filling weights given your measured bulk density for the two compounds (calcium carbonate and lactose monohydrate) (Ref. APF 25th edition – page 61).

2. Size 00 was selected for compounding this prescription. Using the above results in Part 2 and what you have learnt about capsule sizes and their filling weights, discuss the justification of this selection.