atropine sulphate 2mg/kg, allow for 2 minutes for it to be taken up by tissues.little effect is seen on the blood pressure.why?

1. atropine sulphate 2mg/kg, allow for 2 minutes for it to be taken up by tissues.little effect is seen on the blood pressure.why?
2. adrenaline, 5-10ml. effect similar to rise in pressure occurs due to stimulation of of sympathetic receptors in artrioles, but usually the response is greater in magnitude as well as duration after atropine. why?
3. acetylcholine, 20-500ml, the nicotinic effects of acetylcholine are apparent only after large doses given after atropine.why?
4. injecting adrenaline, noradrenaline and Isoprenaline. explain the observed effect?
5. inject propranolo (0.1mg/kg), repeat adrenaline, noradrenaline and isoprenaline.explain the effect observed?

SCIENCEBIOLOGYPHARMACOLOGYBAS01-DN 2610

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