Summarize the pathophysiology of Peptic Ulcer Disease as compared to GERD

Henry, a 58 y/o male, recently reports waking up in the middle of the night with burning abdominal pain. Symptoms occur several nights a week with occasional discomfort in the middle of the afternoon. A bland diet or drinking milk do seem to help and spicy foods aggregate the symptoms. PMH: non-contributory SH: Works in a grocery store, divorced, non-smoker, drinks 1-2 beers/day Allergies: none Meds: 1 325mg ASA daily for cardiovascular prevention ROS: Constitutional: Decrease appetite and 5% weight loss; denies fever ENT: Denies sore throat or drainage Lungs: Occasional dry cough at night Heart: Mid sternum chest burning intermittently Abdomen: Epigastric burning and tenderness, denies constipation or diarrhea.

1)Summarize the pathophysiology of Peptic Ulcer Disease as compared to GERD and explain which one his symptoms most closely represent. Support with evidence. 2) Explain the body’s natural protection against peptic ulcers from a pathophysiology standpoint. 3) What diagnostic testing may be used to further evaluate the symptoms and what might this test tell the healthcare provider?